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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12454708 B1

PDFFull Text
Date of Patent:
Oct. 28, 2025

Filed:

Jan. 06, 2021

Use of biological enzyme for preparing orlistat intermediate, and preparation method

Applicant:

Zein Biotechnology Co., Ltd., Chongqing, CN;

Inventors:

Tianshuai Xu, Chongqing, CN;

Dayong Gong, Chongqing, CN;

Yumei Xiao, Chongqing, CN;

Zhanghong Wang, Chongqing, CN;

Zhichuan Huang, Chongqing, CN;

Shan Huang, Chongqing, CN;

Lei Zhang, Chongqing, CN;

Xin Gao, Chongqing, CN;

Junwei Shen, Chongqing, CN;

Assignee:

ZEIN BIOTECHNOLOGY CO., LTD., Chongqing, CN;

Attorney:

RICKY LAM

Primary Examiner:

Todd M Epstein

Int. Cl.
CPC ...
C12P 7/42 (2006.01); C12N 1/21 (2006.01); C12N 9/04 (2006.01); C12N 15/62 (2006.01);
U.S. Cl.
CPC ...
C12P 7/42 (2013.01); C12N 9/0006 (2013.01); C12N 15/62 (2013.01); C07K 2319/00 (2013.01); C12Y 101/01002 (2013.01); C12Y 101/01047 (2013.01);
Abstract

Provided is a method for biosynthesis of (R)-β-hydroxytetradecanoate compounds. The method comprises the following steps of: reacting β-carbonyl tetradecanoate in a ketoreductase and a glucose dehydrogenase or a fusion enzyme thereof, glucose, NADPand a buffer solution to obtain (R)-β-hydroxytetradecanoate compounds. The method is an enzyme-catalyzed biosynthesis method having simple operations, conventional equipment and an environmentally friendly process, and the prepared product has high purity, high yield and a high ee value.

Find Patent Forward Citations

Xu, Tianshuai. (2025). Use of biological enzyme for preparing orlistat intermediate, and preparation method (U.S. Patent No. 12454708). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12454708

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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