The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 28, 2025
Filed:
Aug. 18, 2021
Wisconsin Alumni Research Foundation, Madison, WI (US);
James A. Thomson, Madison, WI (US);
Nicholas E. Propson, Houston, TX (US);
Michael P. Schwartz, Madison, WI (US);
Zhonggang Hou, Madison, WI (US);
Gene I. Uenishi, Madison, WI (US);
Igor I Slukvin, Verona, WI (US);
William L. Murphy, Waunakee, WI (US);
Jue Zhang, Madison, WI (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Abstract
The present invention relates to methods for deriving human hematopoietic progenitors, primitive macrophages, and microglial cells from human pluripotent stem cells. In particular, provided herein are highly efficient and reproducible methods of obtaining human primitive macrophages and microglia from human pluripotent stem cells, where the primitive macrophages and microglia can be suitable for clinically relevant therapeutic applications.