The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 28, 2025
Filed:
Feb. 28, 2023
Massachusetts Institute of Technology, Cambridge, MA (US);
Children's Medical Center Corporation, Boston, MA (US);
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
Richard O. Hynes, Winchester, MA (US);
Noor Jailkhani, Cambridge, MA (US);
Hidde L. Ploegh, Boston, MA (US);
Yushu J. Xie, Brookline, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Children's Medical Center Corporation, Boston, MA (US);
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
Abstract
Methods for developing disease-related nanobodies and related products and kits are provided. The disease-specific proteins are extracellular matrix (ECM) proteins, domains or epitopes that are associated with various aspects of disease and are not present, or are present in very low quantities, in non-diseased individuals. Highly effective nanobodies capable of specifically binding to these ECM protein epitopes useful in in vivo imaging assays, the detection, diagnosis and treatment of diseases as well as monitoring therapeutic progress in a patient with a disease are provided herein.