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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12453777 B1

PDFFull Text
Date of Patent:
Oct. 28, 2025

Filed:

Mar. 20, 2020

Uses of amphiphiles in immune cell therapy and compositions therefor

Applicant:

Massachusetts Institute of Technology, Cambridge, MA (US);

Inventors:

Darrell J. Irvine, Arlington, MA (US);

Peter C. Demuth, Medford, MA (US);

Assignee:

Massachusetts Institute of Technology, Cambridge, MA (US);

Attorneys:

McCarter & English, LLP

Jill Mello

Primary Examiner:

Gary B Nickol

Assistant Examiner:

Cheom-Gil undefined Cheong

Int. Cl.
CPC ...
A61K 47/54 (2017.01); A61K 39/39 (2006.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/32 (2025.01); A61K 40/42 (2025.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 47/543 (2017.08); A61K 39/39 (2013.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/32 (2025.01); A61K 40/4202 (2025.01); C07K 14/705 (2013.01); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C07K 16/2803 (2013.01); C07K 16/2866 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01);
Abstract

Provided herein are methods for stimulating an immune response to a target cell population or a target tissue in a subject by administering to the subject a composition comprising an amphiphilic ligand conjugate. Such an amphiphilic ligand conjugate can comprise a lipid, one or more cargos (e.g., a CAR ligand, a chimeric cytokine receptor target, a chimeric co-stimulation receptor target, a synNotch receptor target), and optionally a linker.

Find Patent Forward Citations

Irvine, Darrell. (2025). Uses of amphiphiles in immune cell therapy and compositions therefor (U.S. Patent No. 12453777). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12453777

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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