The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 28, 2025
Filed:
Feb. 19, 2020
Applicants:
Rutgers, the State University of New Jersey, New Brunswick, NJ (US);
Houston Methodist Hospital, Houston, TX (US);
Inventor:
Dongfang Liu, Millburn, NJ (US);
Assignees:
Rutgers, The State University of New Jersey, New Brunswick, NJ (US);
Houston Methodist Hospital, Houston, TX (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 40/15 (2025.01); A61K 38/17 (2006.01); A61K 38/20 (2006.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); A61P 35/00 (2006.01); C12N 5/0781 (2010.01); C12N 5/0783 (2010.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 40/15 (2025.01); A61K 38/1774 (2013.01); A61K 38/20 (2013.01); A61K 40/31 (2025.01); A61K 40/4211 (2025.01); A61P 35/00 (2018.01); C12N 5/0635 (2013.01); C12N 5/0636 (2013.01); C12N 5/0646 (2013.01); C12N 15/86 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); A61K 2239/48 (2023.05); C12N 2501/2302 (2013.01); C12N 2501/2315 (2013.01); C12N 2501/2321 (2013.01); C12N 2502/1107 (2013.01); C12N 2740/10043 (2013.01);
Abstract
Disclosed herein are methods and compositions for generating immunotherapeutic cells (e.g., NK and T cells) with enhanced cytotoxicity and capacity for expansion thereof. The methods and compositions disclosed herein can further be used for enhanced expansion of CAR-modified NK and T cells with increased cytotoxicity.