The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 28, 2025
Filed:
May. 01, 2020
Applicant:
Translate Bio, Inc., Lexington, MA (US);
Inventors:
Shrirang Karve, Lexington, MA (US);
Frank Derosa, Lexington, MA (US);
Assignee:
TRANSLATE BIO, INC., Waltham, MA (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/45 (2006.01); A61K 9/127 (2025.01); A61K 38/17 (2006.01); A61K 48/00 (2006.01); C07C 327/30 (2006.01); C07C 329/16 (2006.01); C07D 295/15 (2006.01);
U.S. Cl.
CPC ...
A61K 38/45 (2013.01); A61K 9/127 (2013.01); A61K 38/177 (2013.01); C07C 327/30 (2013.01); C07C 329/16 (2013.01); C07D 295/15 (2013.01); A61K 48/00 (2013.01);
Abstract
The present invention provides, in part, di-thioester cationic lipid compounds or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.