The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 28, 2025

Filed:

Feb. 13, 2020
Applicant:

University of Vermont and State Agricultural College, Burlington, VT (US);

Inventors:

Victor May, Essex, VT (US);

Matthias Brewer, Williston, VT (US);

Jianing Li, South Burlington, VT (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/4045 (2006.01); A61K 31/166 (2006.01); A61K 31/437 (2006.01); C07C 251/80 (2006.01); C07D 209/10 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4045 (2013.01); A61K 31/166 (2013.01); A61K 31/437 (2013.01); C07C 251/80 (2013.01); C07D 209/10 (2013.01); C07D 471/04 (2013.01);
Abstract

The invention relates to compounds that demonstrate efficacy in blocking PACAP receptors (e.g. PAC1) and associated methods of treating neurological diseases or disorders using the disclosed compounds. The neurological diseases or disorders include, but are not limited to, stress-related diseases (e.g. chronic stress, post-traumatic stress disorder (PTSD), anxiety, or general anxiety disorder), pain-related diseases (e.g. chronic pain, primary headache disorders, or migraines), or addiction (e.g. addiction to a substance (e.g. addiction to cocaine, amphetamines, methamphetamine, methylphenidate, nicotine, alcohol, prescription medication, marijuana, tobacco, or an opioid selected from heroin, fentanyl, codeine, hydrocodone, morphine, oxycodone, hydromorphone, and methadone)).


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