The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 28, 2025
Filed:
Feb. 24, 2025
Applicant:
Generation Bio Co., Cambridge, MA (US);
Inventors:
Debra Klatte, Cambridge, MA (US);
Lalita Oonthonpan, Cambridge, MA (US);
Viktoriya Syrovatkina, Cambridge, MA (US);
Anthony Joseph Perniciaro, Cambridge, MA (US);
Salma Merchant, Cambridge, MA (US);
Brandon Michael Johnston, Cambridge, MA (US);
Assignee:
Generation Bio Co., Cambridge, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 9/51 (2006.01); A61K 47/68 (2017.01); A61K 47/69 (2017.01); C07K 16/28 (2006.01); C12N 15/88 (2006.01);
U.S. Cl.
CPC ...
A61K 9/5123 (2013.01); A61K 9/5146 (2013.01); A61K 47/6849 (2017.08); A61K 47/6929 (2017.08); C07K 16/2809 (2013.01); C07K 16/2896 (2013.01); C12N 15/88 (2013.01); C07K 2317/569 (2013.01); C07K 2317/622 (2013.01);
Abstract
The present disclosure provides bispecific stealth lipid nanoparticle (LNP) compositions engineered to target specific tissues or cell-types, e.g., hematopoietic stem cells, to modify the cells with therapeutic nucleic acid encapsulated in the LNP. The present disclosure also provides compositions and methods of making the LNPs and treatment using the same.