The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 2025
Filed:
Sep. 27, 2021
Applicant:
Salk Institute for Biological Studies, La Jolla, CA (US);
Inventors:
Lukas Christoph Bachmann, San Diego, CA (US);
Samuel Lawrence Pfaff, San Diego, CA (US);
Assignee:
Salk Institute for Biological Studies, La Jolla, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 19/34 (2006.01); C12N 15/86 (2006.01); C12Q 1/6813 (2018.01);
U.S. Cl.
CPC ...
C12P 19/34 (2013.01); C12N 15/86 (2013.01); C12Q 1/6813 (2013.01); C12N 2750/14111 (2013.01);
Abstract
Provided herein are synthetic RNA molecules for reconstitution of RNA molecules, including compositions and methods of using these molecules. For example, such molecules can be used to deliver a protein coding sequence over two or more viral vectors (such as AAVs), resulting in reconstitution of the full-length protein in a cell. Such methods can be used to deliver a therapeutic protein, for example to treat a genetic disease or cancer.