The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 2025
Filed:
Nov. 13, 2020
Applicant:
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
Inventors:
Xiaodong Wang, Chapel Hill, NC (US);
Yubai Zhou, Cary, NC (US);
Ransheng Ding, Binhai New District, CN;
Deyu Kong, Chapel Hill, NC (US);
Stephen Frye, Chapel Hill, NC (US);
Assignee:
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, Chapel Hill, NC (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 405/14 (2006.01); A61K 45/06 (2006.01); A61P 7/02 (2006.01); A61P 31/00 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 413/14 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); C07D 401/04 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01);
Abstract
Aminopyrimidine containing compounds that inhibit both Mer tyrosine kinase (MerTK) activity and Tyro3 kinase activity are disclosed herein. Additionally disclosed are methods of synthesis and use of the aminopyrimidine containing compounds as anti-cancer agents, immunostimulatory and immunomodulatory agents, anti-platelet agents, anti-infective agents, and as adjunctive agents.