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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12447464 B1

PDFFull Text
Date of Patent:
Oct. 21, 2025

Filed:

Dec. 22, 2017

Polycationic microfibers and methods of using the same

Applicant:

Duke University, Durham, NC (US);

Inventors:

Jaewoo Lee, Durham, NC (US);

Bruce A. Sullenger, Durham, NC (US);

Jennifer G. Jackman, Durham, NC (US);

Assignee:

Duke University, Durham, NC (US);

Attorney:

Quarles & Brady, LLP

Primary Examiner:

Dirk R Bass

Int. Cl.
CPC ...
B01J 20/26 (2006.01); A01N 1/02 (2006.01); A01N 1/143 (2025.01); A61M 1/34 (2006.01); B01D 39/08 (2006.01); B01D 67/00 (2006.01); B01D 69/02 (2006.01); B01D 69/14 (2006.01); B01D 71/28 (2006.01); B01D 71/40 (2006.01); B01D 71/82 (2006.01); B01J 20/28 (2006.01); B01J 20/30 (2006.01); B01J 20/32 (2006.01); D01F 6/42 (2006.01); D01F 6/56 (2006.01); D06M 15/61 (2006.01);
U.S. Cl.
CPC ...
B01J 20/264 (2013.01); A01N 1/143 (2025.01); B01D 39/083 (2013.01); B01D 67/00042 (2022.08); B01D 69/02 (2013.01); B01D 69/1411 (2022.08); B01D 71/281 (2022.08); B01D 71/401 (2022.08); B01D 71/82 (2013.01); B01J 20/261 (2013.01); B01J 20/28023 (2013.01); B01J 20/3007 (2013.01); B01J 20/321 (2013.01); B01J 20/3272 (2013.01); B01J 20/3293 (2013.01); D01F 6/42 (2013.01); D01F 6/56 (2013.01); D06M 15/61 (2013.01); A61M 1/34 (2013.01); B01D 2239/0421 (2013.01); B01D 2239/0428 (2013.01); B01D 2325/16 (2013.01); D06M 2400/01 (2013.01);
Abstract

Disclosed herein are polycationic microfibers comprising a high-aspect-ratio polymeric core, the polymeric core comprising a blend of a first core polymer and a second core polymer, and a polycationic polymer immobilized on the surface of the polymeric core. The polycationic microfibers are capable of sequestering or clearing nucleic acids, proteins, biomolecular complexes, exosomes, or microparticles from solutions and samples and may be formed into filters or integrated into filtration apparatuses. Also disclosed are methods for sequestering or clearing solutes from solutions and fluids, methods for the treatment of diseases or conditions, and methods for the prevention of diseases or conditions.

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