The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 21, 2025

Filed:

Nov. 23, 2020
Applicant:

The University of Memphis Research Foundation, Memphis, TN (US);

Inventors:

J. Amber Jennings, Memphis, TN (US);

Leslie Pace, Marion, AR (US);

Madison N. Brown, Arlington, TN (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/26 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 9/16 (2006.01); A61K 31/7036 (2006.01); A61K 38/14 (2006.01); A61K 47/34 (2017.01); A61K 47/36 (2006.01); A61P 31/04 (2006.01);
U.S. Cl.
CPC ...
A61K 38/14 (2013.01); A61K 9/0019 (2013.01); A61K 9/0024 (2013.01); A61K 9/06 (2013.01); A61K 9/1694 (2013.01); A61K 31/7036 (2013.01); A61K 47/26 (2013.01); A61K 47/34 (2013.01); A61K 47/36 (2013.01); A61P 31/04 (2018.01);
Abstract

Compositions of chitosan and one or more polyalcohols, such as mannitol and polyethylene glycol, and methods of use thereof, are provided. The disclosed compositions can deliver high concentrations of localized antimicrobials and metabolites to make infections more susceptible to antimicrobials. The disclosed compositions may be used to deliver biologically active agents to an infection at a site of trauma or surrounding an indwelling medical device, to treat an infection caused by persister bacterial cells, and to treat and/or prevent the formation of biofilm bacteria on an indwelling medical device or surrounding tissue.


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