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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12447132 B1

PDFFull Text
Date of Patent:
Oct. 21, 2025

Filed:

May. 01, 2024

Metal oxide encapsulated drug compositions and methods of preparing the same

Applicant:

Applied Materials, Inc., Santa Clara, CA (US);

Inventors:

Colin C. Neikirk, Mountain View, CA (US);

Jonathan Frankel, Los Gatos, CA (US);

Assignee:

Applied Materials, Inc., Santa Clara, CA (US);

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Shirley V Gembeh

Int. Cl.
CPC ...
A61K 9/50 (2006.01); A61J 3/07 (2006.01); A61K 31/405 (2006.01); A61K 31/424 (2006.01); A61K 31/43 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 31/7048 (2006.01); A61K 47/58 (2017.01); C07K 16/22 (2006.01); C07K 16/28 (2006.01); C07K 16/32 (2006.01); C23C 16/40 (2006.01); C23C 16/44 (2006.01); C23C 16/455 (2006.01); C23C 16/458 (2006.01);
U.S. Cl.
CPC ...
A61K 9/5089 (2013.01); A61J 3/07 (2013.01); A61K 9/501 (2013.01); A61K 31/405 (2013.01); A61K 31/424 (2013.01); A61K 31/43 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 31/7048 (2013.01); A61K 47/58 (2017.08); C07K 16/22 (2013.01); C07K 16/2833 (2013.01); C07K 16/32 (2013.01); C23C 16/40 (2013.01); C23C 16/403 (2013.01); C23C 16/405 (2013.01); C23C 16/4417 (2013.01); C23C 16/45525 (2013.01); C23C 16/45555 (2013.01); C23C 16/458 (2013.01); C07K 2317/24 (2013.01); C07K 2317/94 (2013.01);
Abstract

A method of preparing a pharmaceutical composition having a drug-containing core enclosed by one or more metal oxide materials is provided. The method includes the sequential steps of (a) loading the particles comprising the drug into a reactor, (b) applying a vaporous or gaseous metal precursor to the particles in the reactor, (c) performing one or more pump-purge cycles of the reactor using inert gas, (d) applying a vaporous or gaseous oxidant to the particles in the reactor, and (e) performing one or more pump-purge cycles of the reactor using inert gas. The temperature of the particles does not exceed 35° C. This produces a pharmaceutical composition comprising a drug containing core enclosed by one or more metal oxide materials.

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