The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 21, 2025

Filed:

Dec. 05, 2022
Applicant:

University of Central Florida Research Foundation, Inc., Orlando, FL (US);

Inventors:

Sudipta Seal, Oviedo, FL (US);

Swetha Barkam, Orlando, FL (US);

Amitava Adhikary, Rochester, MI (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/51 (2006.01); A61K 9/14 (2006.01); A61K 33/244 (2019.01); C01F 17/235 (2020.01); B82Y 5/00 (2011.01); B82Y 30/00 (2011.01); B82Y 40/00 (2011.01);
U.S. Cl.
CPC ...
A61K 9/14 (2013.01); A61K 9/51 (2013.01); A61K 33/244 (2019.01); C01F 17/235 (2020.01); A61K 9/5115 (2013.01); A61K 9/5192 (2013.01); B82Y 5/00 (2013.01); B82Y 30/00 (2013.01); B82Y 40/00 (2013.01); C01P 2002/01 (2013.01); C01P 2002/84 (2013.01); C01P 2002/85 (2013.01); C01P 2002/86 (2013.01); C01P 2004/62 (2013.01); C01P 2004/64 (2013.01);
Abstract

Cerium oxide nanoparticles (CNPs) have been proven to exhibit antioxidant properties attributed to its surface oxidation states (Ce4+ to Ce3+ and vice versa) mediated at the oxygen vacancies on the surface of CNPs. Different anions in precursor cerium salts were used to prepare CNPs resulting in disclosed CNPs with varying physicochemical properties such as dispersion stability, hydrodynamic size, and the signature surface chemistry. The antioxidant catalytic activity and oxidation potentials of different CNPs have been significantly altered with the change of anions in the precursor salts. For one, CNPs prepared using precursor salts containing NOand Clions exhibited increased antioxidant activity than previously thought possible. The change in oxidation potentials of CNPs with the change in concentration of the nitrate and chloride ions indicates the disclosed CNP's have different surface chemistry and antioxidant properties. These compositions and methods of their synthesis are disclosed.


Find Patent Forward Citations

Loading…