Multimodal metrics for remote monitoring of condition progression

Abstract

A system for identifying efficacious markers comprises memory storing collected multimodal digital markers from a first cohort experiencing a sign onset and a second cohort experiencing a non-sign onset. The system further comprises selection logic that identifies a subset of markers that best capture differences between the sign and non-sign onsets. The system further comprises responsiveness logic that determines a responsiveness parameter that specifies a rate of change in the subset. The system further comprises time to detect change logic that determines a time parameter that specifies a time required to detect change in the subset. The system further comprises sample size logic that determines how the responsiveness parameter and the time parameter change depending on sample size. The system further comprises sensitivity logic that determines a sensitivity parameter that specifies whether the subset detects condition deterioration during intervals when no changes are reported in an external standard.