The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2025
Filed:
Nov. 19, 2024
Applicant:
The Florida State University Research Foundation, Inc., Tallahassee, FL (US);
Inventors:
Changchun Zeng, Tallahassee, FL (US);
Yan Li, Tallahassee, FL (US);
Xingchi Chen, Tallahassee, FL (US);
Assignee:
The Florida State University Research Foundation, Inc., Tallahassee, FL (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/077 (2010.01); C12N 5/071 (2010.01); C12N 5/079 (2010.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5082 (2013.01); C12N 5/0618 (2013.01); C12N 5/0691 (2013.01); C12N 5/0697 (2013.01); G01N 33/5023 (2013.01); C12N 2513/00 (2013.01); C12N 2533/40 (2013.01); C12N 2537/10 (2013.01);
Abstract
Disclosed herein are spinal cord models including a cell scaffold including methacrylated hyaluronic acid (HAMA) and dopamine-modified hyaluronic acid (HA-Cat), and a spinal cord spheroid or organoid or a fragment thereof cultured on the cell scaffold. Said spinal cord spheroids or organoids or fragments thereof can be co-cultured with blood vessel spheroid organoids to form blood-spinal cord barrier models. Also disclosed herein are methods of making and using said models.