The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2025
Filed:
Jan. 20, 2023
Applicant:
Janssen Biotech, Inc., Horsham, PA (US);
Inventor:
Jean Xu, Skillman, NJ (US);
Assignee:
Janssen Biotech, Inc., Horsham, PA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0676 (2013.01); C12N 2501/117 (2013.01); C12N 2501/119 (2013.01); C12N 2501/16 (2013.01); C12N 2501/385 (2013.01); C12N 2501/40 (2013.01); C12N 2501/41 (2013.01); C12N 2501/415 (2013.01); C12N 2501/70 (2013.01); C12N 2501/727 (2013.01); C12N 2506/02 (2013.01); C12N 2533/90 (2013.01);
Abstract
The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express NKX6.1 and insulin and minimal amounts of glucagon.