The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2025
Filed:
Jul. 29, 2020
Applicant:
The Children's Hospital of Philadelphia, Philadelphia, PA (US);
Inventors:
Andrei Thomas-Tikhonenko, Philadelphia, PA (US);
Sisi Zheng, Philadelphia, PA (US);
Assignee:
The Children's Hospital of Philadelphia, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61P 35/02 (2006.01); C07K 14/725 (2006.01); C07K 16/30 (2006.01); C12N 5/16 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2803 (2013.01); C07K 14/7051 (2013.01); C07K 16/30 (2013.01); C12N 5/16 (2013.01); C07K 2317/24 (2013.01); C07K 2317/34 (2013.01); C07K 2317/569 (2013.01); C07K 2319/03 (2013.01);
Abstract
The present disclosure is directed to antibodies binding to CD22-Del.ex5-6 protein and methods of using such antibodies to treat cancers that express or overexpress CD22-Del.ex5-6 protein. Specifically, the disclosure provides a method of treating cancer comprising contacting a cancer cell in a subject with an antibody or antibody derivative that binds selectively to CD22-Del.ex5-6 protein, or to a peptide having the sequence of QLNVKHPPKKVTTVIQNP (SEQ ID NO: 1).