The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2025
Filed:
Sep. 12, 2019
Applicant:
The Rockefeller University, New York, NY (US);
Inventors:
Michel Nussenzweig, New York, NY (US);
Randal R. Ketchem, Snohomish, WA (US);
Christine C. Siska, Seattle, WA (US);
Alison J. Gillespie, Seattle, WA (US);
Rutilio H. Clark, Bainbridge Island, WA (US);
Bruce A Kerwin, Bainbridge Island, WA (US);
Assignee:
The Rockefeller University, New York, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/10 (2006.01); A61K 39/00 (2006.01); A61K 45/06 (2006.01); A61P 31/18 (2006.01);
U.S. Cl.
CPC ...
C07K 16/1045 (2013.01); A61K 45/06 (2013.01); A61P 31/18 (2018.01); A61K 2039/507 (2013.01);
Abstract
The present disclosure provides optimized broadly-neutralizing anti-HIV antibodies, having modified light chain variable regions and/or heavy chain variable regions leading to improved biophysical characteristics. The present disclosure also provides methods for producing these anti-HIV antibodies and methods of use thereof.