The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 14, 2025

Filed:

Oct. 05, 2022
Applicant:

Juventas Cell Therapy Ltd., Tianjin, CN;

Inventors:

Yun Liu, Tianjin, CN;

Lin Shi, Tianjin, CN;

Lulu Lv, Tianjin, CN;

Pan Xie, Tianjin, CN;

Mengmeng Cao, Tianjin, CN;

Wang Yang, Tianjin, CN;

Jiaxing Yang, Tianjin, CN;

Fei Wang, Tianjin, CN;

Rui Wang, Tianjin, CN;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); A61P 35/02 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); C12N 5/0783 (2010.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70521 (2013.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/4211 (2025.01); A61P 35/02 (2018.01); C07K 14/70517 (2013.01); C07K 14/70578 (2013.01); C07K 16/2803 (2013.01); C07K 16/2887 (2013.01); C12N 5/0636 (2013.01); C12N 5/0646 (2013.01); C12N 15/86 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); A61K 2239/48 (2023.05);
Abstract

Provided in the present disclosure is a method for using a four-plasmid system to prepare modified immune effector cells. The method comprises: forming a lentivirus by using four plasmids within 293T cells, extracting and obtaining the lentivirus, then transfecting immune effector cells by using the lentivirus, and expressing a chimeric antigen receptor. Also provided in the present disclosure is a use of the immune effector cell obtained by using the described method and of a composition containing the immune effector cell.


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