The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 14, 2025

Filed:

Sep. 17, 2019
Applicant:

Zhejiang Doer Biologics Corporation, Zhejiang, CN;

Inventor:

Yanshan Huang, Zhejiang, CN;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/08 (2006.01); A61K 38/00 (2006.01); A61K 47/64 (2017.01); C07K 14/495 (2006.01); C07K 14/605 (2006.01); C07K 14/61 (2006.01); C12N 9/78 (2006.01);
U.S. Cl.
CPC ...
C07K 7/08 (2013.01); A61K 47/64 (2017.08); C07K 14/495 (2013.01); C07K 14/605 (2013.01); C07K 14/61 (2013.01); C12N 9/78 (2013.01); C12Y 305/03001 (2013.01); A61K 38/00 (2013.01); C07K 2319/31 (2013.01);
Abstract

The present disclosure provides an artificial recombinant protein for improving the performance of an active protein or polypeptide and the use thereof. The present disclosure provides a polypeptide unit (U) or a polypeptide complex unit (PU) that is very effective for prolonging the biological activity and half-life of a protein or polypeptide or improving the in-vivo and in-vitro properties of a protein or polypeptide, the polypeptide unit (U) being mainly composed of proline (P), alanine (A) and glutamic acid (E). The present disclosure also provides a biologically active fusion protein comprising the polypeptide unit (U) or the polypeptide complex unit (PU) and an active protein or polypeptide connected thereto.


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