The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2025
Filed:
May. 05, 2021
Amgen Inc., Thousand Oaks, CA (US);
Austin G. Smith, Cary, NC (US);
Jason S. Tedrow, Salem, MA (US);
Gabrielle St-Pierre, Thousand Oaks, CA (US);
Oliver Ralf Thiel, Lexington, MA (US);
Liang Huang, Thousand Oaks, CA (US);
Philipp C. Roosen, Thousand Oaks, CA (US);
John T. Colyer, Newbury Park, CA (US);
Kyle D. Baucom, Ventura, CA (US);
Ari Ericson, Thousand Oaks, CA (US);
Matthew G. Beaver, Natick, MA (US);
Rahul P. Sangodkar, Boston, MA (US);
Michael A. Lovette, Camarillo, CA (US);
Robert Ronald Milburn, Belmont, CA (US);
Alan H. Cherney, Somerville, MA (US);
Sheng Cui, Lexington, MA (US);
AMGEN INC., Thousand Oaks, CA (US);
Abstract
Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound F that can be used to prepare them where the variable PG is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.