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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12441735 B1

PDFFull Text
Date of Patent:
Oct. 14, 2025

Filed:

Jan. 21, 2025

Nitrogen-containing heterocyclic compound having nrf2 activation effect

Applicant:

Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;

Inventors:

Atsushi Kimbara, Kamakura, JP;

Takeo Harada, Gotemba, JP;

Susumu Komiyama, Kamakura, JP;

Mizuki Okuyama, Kamakura, JP;

Yoshihito Ohtake, Gotemba, JP;

Yoshihisa Murata, Gotemba, JP;

Rie Saito, Kamakura, JP;

Assignee:

CHUGAI SEIYAKU KABUSHIKI KAISHA, Tokyo, JP;

Attorney:

Nixon & Vanderhye P.C.

Primary Examiner:

Kahsay Habte

Int. Cl.
CPC ...
C07D 491/08 (2006.01); A61K 31/472 (2006.01); A61K 31/4725 (2006.01); A61K 31/502 (2006.01); A61K 31/536 (2006.01); A61K 31/5365 (2006.01); A61K 31/5377 (2006.01); A61K 31/538 (2006.01); A61K 31/5383 (2006.01); A61K 31/5386 (2006.01); A61K 31/541 (2006.01); A61K 31/5415 (2006.01); A61K 31/55 (2006.01); A61K 31/551 (2006.01); C07D 217/06 (2006.01); C07D 237/32 (2006.01); C07D 265/02 (2006.01); C07D 265/16 (2006.01); C07D 401/10 (2006.01); C07D 401/14 (2006.01); C07D 403/10 (2006.01); C07D 413/10 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/10 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 487/10 (2006.01); C07D 491/107 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 491/08 (2013.01); A61K 31/472 (2013.01); A61K 31/4725 (2013.01); A61K 31/502 (2013.01); A61K 31/536 (2013.01); A61K 31/5365 (2013.01); A61K 31/5377 (2013.01); A61K 31/538 (2013.01); A61K 31/5383 (2013.01); A61K 31/5386 (2013.01); A61K 31/541 (2013.01); A61K 31/5415 (2013.01); A61K 31/55 (2013.01); A61K 31/551 (2013.01); C07D 217/06 (2013.01); C07D 237/32 (2013.01); C07D 265/02 (2013.01); C07D 265/16 (2013.01); C07D 401/10 (2013.01); C07D 401/14 (2013.01); C07D 403/10 (2013.01); C07D 413/10 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/10 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 487/10 (2013.01); C07D 491/107 (2013.01); C07D 519/00 (2013.01);
Abstract

Provided is a low-molecular compound or a salt thereof, or a solvate thereof which has the ability to activate Nrf2. The present invention provides a compound represented by the formula (1) or a salt thereof, or a solvate thereof, wherein Xis CRor N, Xis CRor N, R, Rand Rare each independently selected from the group consisting of hydrogen, halogen and C-Calkoxy, X, Xand Xare each independently selected from the group consisting of CH, O, NH, S and C═O, Y is C-Caryl optionally having a substituent or 5- to 10-membered heteroaryl optionally having a substituent, and Z is C-Caryl optionally having a substituent, 5- to 10-membered heteroaryl optionally having a substituent or C-Calkyl optionally having a substituent.

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