The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 14, 2025

Filed:

Nov. 14, 2022
Applicant:

Jichi Medical University, Tokyo, JP;

Inventors:

Hitoshi Osaka, Shimotsuke, JP;

Akihiko Miyauchi, Shimotsuke, JP;

Eriko Jimbo, Shimotsuke, JP;

Mizuki Kobayashi, Shimotsuke, JP;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 491/06 (2006.01); A61K 31/473 (2006.01); A61K 31/4741 (2006.01); C07D 221/18 (2006.01);
U.S. Cl.
CPC ...
C07D 491/06 (2013.01); A61K 31/473 (2013.01); A61K 31/4741 (2013.01); C07D 221/18 (2013.01);
Abstract

The present invention provides a means whereby it is possible to clarify the mechanism of manifestation of symptoms, an illness, or dysfunction caused by mitochondrial dysfunction and prevent or treat symptoms, an illness, or dysfunction relating to the same mechanism of manifestation. One embodiment of the present invention relates to a ferroptosis inhibitor containing a compound represented by formula (I), a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof as an active ingredient. Another embodiment of the present invention relates to a medicine that contains the ferroptosis inhibitor as an active ingredient and is for use in the prevention or treatment of symptoms, an illness, or dysfunction relating to ferroptosis. Yet another embodiment of the present invention relates to a compound represented by formula (I-1), a salt thereof, or a solvate thereof.


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