The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2025
Filed:
Dec. 20, 2019
Amgen Inc., Thousand Oaks, CA (US);
Nuria A Tamayo, Newbury Park, CA (US);
Abhisek Banerjee, Karnataka, IN;
Jian Jeffrey Chen, San Diego, CA (US);
Kexue Li, Newbury, CA (US);
Liping H. Pettus, Thousand Oaks, CA (US);
Matthew Paul Bourbeau, Woodland Hills, CA (US);
Lei Jia, San Diego, CA (US);
AMGEN INC., Thousand Oaks, CA (US);
Abstract
The present invention relates to chemical compounds having a general formula (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.