The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2025
Filed:
Nov. 07, 2023
Applicant:
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Inventors:
Assignee:
DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 211/44 (2006.01); A61P 35/00 (2006.01); C07D 211/58 (2006.01); C07D 213/30 (2006.01); C07D 239/78 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 413/04 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 211/44 (2013.01); A61P 35/00 (2018.01); C07D 211/58 (2013.01); C07D 213/30 (2013.01); C07D 239/78 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 413/04 (2013.01); C07D 471/04 (2013.01);
Abstract
The present application relates to compounds comprising an ester, a thioester, or a hydrazide moiety and methods of synthesizing these compounds. The present application also relates to pharmaceutical compositions containing the compounds and methods of treating cell proliferative disorders mediated by the Hedgehog (Hh) signaling pathway, such as cancer, by administering the compounds and pharmaceutical compositions to subjects in need thereof.