The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2025
Filed:
Dec. 01, 2020
The Charles Stark Draper Laboratory Inc., Cambridge, MA (US);
Jeffrey Borenstein, Newton, MA (US);
Nathan Moore, Canton, MA (US);
Daniel Doty, Arlington, MA (US);
Timothy Haggerty, Concord, MA (US);
Joseph Charest, Jamaica Plain, MA (US);
Alla Gimbel, Medford, MA (US);
Vienna Mott, Cambridge, MA (US);
Brett Isenberg, Newton, MA (US);
Hesham Azizgolshani, Belmont, MA (US);
Brian Cain, Cambridge, MA (US);
Mark Mescher, West Newton, MA (US);
The Charles Stark Draper Laboratory Inc., Cambridge, MA (US);
Abstract
A microfluidic device for modeling a tumor-immune microenvironment can include a multiwell plate defining a plurality of microenvironment units fluidically coupled with a plurality of wells. Each microenvironment unit of the plurality of microenvironment units can include one or more compartments. Each microenvironment unit can include a trapping feature positioned within the one or more compartments. The trapping feature can be defined by a portion of at least one of a sidewall or a floor of the one or more compartments. The trapping feature can restrict movement of a tissue sample introduced into the one or more compartments and to allow fluid to flow past the tissue sample. The microfluidic device can include a plurality of micropumps each coupled with a respective well and configured to control movement of a respective fluid sample through each respective well.