The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2025
Filed:
Mar. 11, 2022
Applicant:
Vrije Universiteit Brussel, Brussels, BE;
Inventors:
Tony Lahoutte, Ganshoren, BE;
Matthias D'Huyvetter, Antwerp, BE;
Jens De Vos, Strombeek-Bever, BE;
Nick Devoogdt, Eppegem-Zemst, BE;
Assignee:
Vrije Universiteit Brussel, Brussels, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 51/10 (2006.01); A61P 35/00 (2006.01); C07K 16/30 (2006.01); C07K 16/32 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 51/1096 (2013.01); A61K 51/1051 (2013.01); A61K 51/1093 (2013.01); A61P 35/00 (2018.01); C07K 16/30 (2013.01); C07K 16/32 (2013.01); A61K 2039/505 (2013.01); A61K 2039/54 (2013.01); C07K 2317/22 (2013.01); C07K 2317/565 (2013.01); C07K 2317/569 (2013.01);
Abstract
Provided herein are methods, kits, and compositions for stratifying and treating subjects, e.g., subjects having cancer. In some examples, the methods involve use of a radiolabelled heavy chain variable domain derived from a heavy chain antibody (V), or a functional fragment thereof, as both a screening agent and a treatment agent. In some examples, the V, or a functional fragment thereof, that is radiolabelled with a radioisotope that is both a γ-emitter and β-emitter.