The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2025
Filed:
Sep. 03, 2020
Applicant:
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Inventors:
Naresha Saligrama, Stanford, CA (US);
Mark M. Davis, Atherton, CA (US);
Assignee:
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61P 25/28 (2006.01); C07K 14/005 (2006.01); C07K 14/725 (2006.01); C07K 14/74 (2006.01); C07K 16/28 (2006.01); C07K 19/00 (2006.01); G01N 33/50 (2006.01); G01N 33/564 (2006.01);
U.S. Cl.
CPC ...
A61K 39/0008 (2013.01); A61P 25/28 (2018.01); C07K 14/005 (2013.01); C07K 14/7051 (2013.01); C07K 14/70539 (2013.01); C07K 16/2833 (2013.01); C07K 19/00 (2013.01); G01N 33/505 (2013.01); G01N 33/564 (2013.01); G01N 2800/285 (2013.01);
Abstract
Provided herein are methods and compositions for diagnosis and treatment of multiple sclerosis. Compositions and methods are provided, relating to novel peptides involved in autoimmune disease. In the experiments described herein, an unbiased approach was used to screen pathogenic CD4+ T cells from patients with multiple sclerosis (MS), and to determine the antigenic specificity of the T cell receptors (TCR) expressed by these pathogenic cells.