The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2025
Filed:
Sep. 15, 2022
Applicant:
Keros Therapeutics, Inc., Lexington, MA (US);
Inventors:
Jasbir S. Seehra, Lexington, MA (US);
Jennifer Lachey, Lincoln, MA (US);
Elissa Furutani, Belmont, MA (US);
Assignee:
Keros Therapeutics, Inc., Lexington, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); A61K 35/19 (2015.01); C07K 14/78 (2006.01);
U.S. Cl.
CPC ...
A61K 38/179 (2013.01); A61K 35/19 (2013.01); C07K 14/78 (2013.01); C07K 2319/30 (2013.01);
Abstract
The invention features polypeptides that include an extracellular ActRIIB variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRIIB variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions containing said polypeptides and methods of using the polypeptides to treat diseases and conditions including neuromuscular diseases, osteogenesis imperfecta, myelofibrosis, thrombocytopenia, neutropenia, and metabolic disease.