The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 14, 2025

Filed:

Aug. 10, 2023
Applicant:

Pharma Mar, S.a., Madrid, ES;

Inventors:

Carmen Kahatt, Madrid, ES;

José María Fernandez, Madrid, ES;

Salvador Fudio, Madrid, ES;

Arturo Soto, Madrid, ES;

Pilar Lardelli, Madrid, ES;

Cristian Fernandez, Madrid, ES;

Assignee:

PHARMA MAR, S.A., Madrid, ES;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/4995 (2006.01); A61K 9/00 (2006.01); A61K 31/4738 (2006.01); A61K 31/4745 (2006.01); A61K 31/573 (2006.01); A61K 38/19 (2006.01); A61P 11/00 (2006.01); A61P 35/00 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4995 (2013.01); A61K 9/0019 (2013.01); A61K 31/4738 (2013.01); A61K 31/4745 (2013.01); A61K 31/573 (2013.01); A61K 38/193 (2013.01); A61P 11/00 (2018.01); A61P 35/00 (2018.01); C07D 519/00 (2013.01); C07B 2200/13 (2013.01);
Abstract

Provided are methods for the treatment of SCLC patients by administering therapeutic amounts of lurbinectedin by intravenous infusion. Also provided are methods of treating cancer by administering lurbinectedin in combination with other anticancer drugs, in particular topoisomerase inhibitors. The invention further relates to the administration of lurbinectedin in combination with anti-emetic agents for effective control of symptoms related to nausea and vomiting, reduced lurbinectedin dosages to achieve a safer administration and an increase in the number of treatment cycles. Stable lyophilized formulations of lurbinectedin are also provided.


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