The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2025
Filed:
May. 03, 2019
University of Pittsburgh— of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Stephen Francis Badylak, West Lafayette, IN (US);
George S. Hussey, Cranberry Township, PA (US);
Heth Turnquist, Pittsburgh, PA (US);
Jenna Lynn Dziki, Pittsburgh, PA (US);
Quan Liu, Shenzhen, CN;
Zhongqiang Zhang, Changsha, CN;
University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Abstract
Methods are disclosed for treating a subject with a disorder, such as, but not limited to, a) fibrosis of an organ or tissue; b) solid organ transplant rejection; or c) a cardiac disease that is not myocardial infarction or myocardial ischemia. These methods include selecting a subject having or at risk of having the disorder, and administering to the subject a therapeutically effective amount of isolated nanovesicles derived from an extracellular matrix, wherein the nanovesicles contain interleukin (IL)-33 and comprise lysyl oxidase, and wherein the nanovesicles a) do not express CD63 or CD81, or b) are CD63CD81. In additional embodiments, methods are disclosed for increasing myoblast differentiation.