The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2025
Filed:
Jul. 25, 2019
Lexent Bio, Inc., Cambridge, MA (US);
Timothy Wilson, San Diego, CA (US);
Haluk Tezcan, San Francisco, CA (US);
John Spinosa, San Francisco, CA (US);
Alexander Robertson, San Francisco, CA (US);
Rohith Srivas, San Francisco, CA (US);
Neil Peterman, San Francisco, CA (US);
Nicole Lambert, San Francisco, CA (US);
Peter George, San Francisco, CA (US);
Ram Yalamanchili, San Francisco, CA (US);
Kenneth Nesmith, San Francisco, CA (US);
Lexent Bio, Inc., Cambridge, MA (US);
Abstract
The present disclosure provides methods and systems for nucleic acid sequencing. Such systems and methods may use a single flow cell to perform unbiased and/or biased sequencing to generate libraries of nucleic acid molecules. An aspect of the present disclosure provides a method for increasing complexity of a sample for sequencing, the method comprising: providing a first nucleic acid sample having a first degree of complexity that differs from a desired degree of complexity; providing a second nucleic acid sample having a second degree of complexity that differs from the first degree of complexity and that differs from the desired degree of complexity; pooling at least a portion of the first nucleic acid sample and at least a portion of the second nucleic acid sample, thereby generating a pooled nucleic acid sample having the desired degree of complexity; and sequencing at least a portion of the pooled nucleic acid sample.