The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 07, 2025

Filed:

Oct. 27, 2020
Applicants:

The Broad Institute, Inc., Cambridge, MA (US);

Massachusetts Institute of Technology, Cambridge, MA (US);

President and Fellows of Harvard College, Cambridge, MA (US);

Inventors:

Feng Zhang, Cambridge, MA (US);

Bernd Zetsche, Cambridge, MA (US);

Amit Choudhary, Cambridge, MA (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/22 (2006.01); A01K 67/0275 (2024.01); A61K 48/00 (2006.01); C07K 14/72 (2006.01); C12N 9/06 (2006.01); C12N 15/10 (2006.01); C12N 15/90 (2006.01);
U.S. Cl.
CPC ...
C12N 9/22 (2013.01); A01K 67/0275 (2013.01); A61K 48/005 (2013.01); C07K 14/721 (2013.01); C12N 9/003 (2013.01); C12N 15/102 (2013.01); C12N 15/907 (2013.01); C12Y 105/01003 (2013.01); A01K 2207/10 (2013.01); A01K 2217/05 (2013.01); A01K 2227/105 (2013.01); C07K 2319/00 (2013.01); C07K 2319/095 (2013.01);
Abstract

The disclosure includes non-naturally occurring or engineered CRISPR Cas9, each associated with at least one destabilization domain (DD), along with compositions, systems and complexes involving the DD-CRISPR Cas9, nucleic acid molecules and vectors encoding the same, delivery systems involving the same, uses therefor.


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