The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 07, 2025

Filed:

Jan. 30, 2023
Applicant:

Abclonal Science, Inc., Woburn, MA (US);

Inventors:

Dapeng Sun, Lexington, MA (US);

Aine Quimby, Newburyport, MA (US);

Zhenyu Zhu, Lynnfield, MA (US);

Assignee:

AbClonal Science, Inc., Woburn, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/16 (2006.01); C08B 37/08 (2006.01);
U.S. Cl.
CPC ...
C12N 9/16 (2013.01); C08B 37/003 (2013.01); C12Y 301/30002 (2013.01);
Abstract

Either wild type or mutantNuclease ('SMN') is engineered to display a C-terminal Chitin Binding Domain (CBD-tag), followed, at the C-terminus side of the CBD-tag, by a poly-histidine tag (His-tag), where the His-tag is preferably a 6-mer and preferably is preceded by a Gly-Ser linker, thereby generating a recombinant SMN protein that retains dual affinity tags (a CBD-tag and a His-tag) at the C-terminus, to make it easily removed from a reaction solution following digestion of nucleic acids in the reaction mixture. It can also be used for binding SMN to a solid support for use in nucleic acid digestion in a sample contacted with the solid support.


Find Patent Forward Citations

Sun, Dapeng. (2025). Double tagged serratia marcescens nuclease (U.S. Patent No. 12435319). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12435319

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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