The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2025
Filed:
Feb. 28, 2022
Shandong Focusfreda Biotech Co., Ltd, Shandong, CN;
Lei Liu, Shandong, CN;
Chunxi Wang, Shandong, CN;
Qing Li, Shandong, CN;
Chuanli Kang, Shandong, CN;
Jingjing Sun, Shandong, CN;
Liwei Tang, Shandong, CN;
Qiang Liu, Shandong, CN;
Shaojie Lian, Shandong, CN;
Meixia Zhang, Shandong, CN;
Mengyi Zhang, Shandong, CN;
Ququan Li, Shandong, CN;
Shuai Du, Shandong, CN;
SHANDONG FOCUSFREDA BIOTECH CO., LTD, Shandong, CN;
Abstract
The present invention relates to a preparation method for acetylated sodium hyaluronate, which pertains to the field of organic chemical synthesis, characterized in that, the preparation method includes the following steps: in the protective atmosphere of inert gas, subjecting a hyaluronate and an acetic anhydride to a catalytic reaction in an organic solvent with a catalyst added, adding a water absorbent during the reaction, obtaining a reaction liquid, subjecting a reaction liquid to post treatment, separation, purification, and drying to obtain a product. A too high or too low degree of substitution is effectively avoided in the present invention, so as to obtain a product with a degree of substitution of acetyl groups ranging from 2.7 to 3.2, with mild reactive materials and reacting conditions, and simple separation and purification steps.