The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2025
Filed:
Apr. 21, 2021
The Uab Research Foundation, Birmingham, AL (US);
Southern Research Institute, Birmingham, AL (US);
The United States Government As Represented BY the Department of Veterans Affairs, Washington, DC (US);
Louis B. Nabors, Birmingham, AL (US);
Natalia Filippova, Birmingham, AL (US);
Xiuhua Yang, Birmingham, AL (US);
Subramaniam Ananthan, Birmingham, AL (US);
Vibha Pathak, Birmingham, AL (US);
Peter King, Birmingham, AL (US);
The UAB Research Foundation, Birmingham, AL (US);
Southern Research Institute, Birmingham, AL (US);
The United States Government as Represented by the Department of Veteran Affairs, Washington, DC (US);
Abstract
This disclosure provides compounds that inhibit RNA-binding proteins, such as Human antigen R protein (HuR). The compounds described herein have a high affinity for HuR multimers and inhibit the pathological processes that promote cancer and inflammation. The compounds are highly water-soluble and have good biodistribution for both systemic and central nervous system disease processes. The compounds provide a unique therapeutic option for disease processes related to neoplastic progression or acute or chronic inflammation.