The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2025
Filed:
Jan. 06, 2021
Applicant:
Guide Therapeutics, Llc, Cambridge, MA (US);
Inventors:
Gregory Lawrence Hamilton, Atlanta, GA (US);
Neeraj Narendra Patwardhan, Atlanta, GA (US);
Cory Dane Sago, Atlanta, GA (US);
Mina Fawzy Gaballa Shehata, Dunwoody, GA (US);
Milloni Balwantkumar Chhabra, Dunwoody, GA (US);
Assignee:
Guide Therapeutics, LLC, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 205/04 (2006.01); A61K 9/1271 (2025.01); A61K 47/10 (2017.01); A61K 47/24 (2006.01); A61K 47/28 (2006.01); C07C 229/30 (2006.01); C07D 207/06 (2006.01); C07D 207/09 (2006.01); C07D 211/14 (2006.01); C07D 211/34 (2006.01); C07D 265/30 (2006.01); C07D 295/145 (2006.01); C07D 319/06 (2006.01); C07D 401/04 (2006.01); C07D 405/12 (2006.01); C07D 471/04 (2006.01); C07D 487/08 (2006.01); A61K 9/51 (2006.01); B82Y 5/00 (2011.01); B82Y 30/00 (2011.01); B82Y 40/00 (2011.01); C07C 219/22 (2006.01); C07D 207/08 (2006.01); C07D 207/14 (2006.01); C07D 207/16 (2006.01); C07D 211/58 (2006.01); C07D 211/62 (2006.01); C07D 213/36 (2006.01); C07D 241/04 (2006.01); C07D 243/08 (2006.01); C07D 295/088 (2006.01); C07D 295/096 (2006.01); C07D 295/13 (2006.01); C07D 295/15 (2006.01); C07D 451/06 (2006.01); C07D 455/02 (2006.01);
U.S. Cl.
CPC ...
C07D 205/04 (2013.01); A61K 9/1271 (2013.01); A61K 47/10 (2013.01); A61K 47/24 (2013.01); A61K 47/28 (2013.01); C07C 229/30 (2013.01); C07D 207/06 (2013.01); C07D 207/09 (2013.01); C07D 211/14 (2013.01); C07D 211/34 (2013.01); C07D 265/30 (2013.01); C07D 295/145 (2013.01); C07D 319/06 (2013.01); C07D 401/04 (2013.01); C07D 405/12 (2013.01); C07D 471/04 (2013.01); C07D 487/08 (2013.01); A61K 9/5123 (2013.01); B82Y 5/00 (2013.01); B82Y 30/00 (2013.01); B82Y 40/00 (2013.01); C07C 219/22 (2013.01); C07D 207/08 (2013.01); C07D 207/14 (2013.01); C07D 207/16 (2013.01); C07D 211/58 (2013.01); C07D 211/62 (2013.01); C07D 213/36 (2013.01); C07D 241/04 (2013.01); C07D 243/08 (2013.01); C07D 295/088 (2013.01); C07D 295/096 (2013.01); C07D 295/13 (2013.01); C07D 295/15 (2013.01); C07D 451/06 (2013.01); C07D 455/02 (2013.01);
Abstract
Lipid nanoparticle compositions for delivery of nucleic acids are described. In various embodiments the lipid nanoparticle contains an ionizable lipid of the Formula (I). Methods of using such lipid nanoparticle compositions to achieve targeted delivery of therapeutic cargo without the need for a targeting ligand are also provided.