The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 07, 2025

Filed:

Oct. 01, 2019
Applicant:

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Inventors:

Gillie A. Roth, Stanford, CA (US);

Eric Andrew Appel, Stanford, CA (US);

Mark Davis, Stanford, CA (US);

Emily C. Gale, Stanford, CA (US);

Santiago Correa, Stanford, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/06 (2006.01); A61K 9/00 (2006.01); A61K 9/51 (2006.01); A61K 39/015 (2006.01); A61K 39/145 (2006.01); A61K 39/21 (2006.01); A61K 39/39 (2006.01); A61K 45/00 (2006.01); A61K 47/38 (2006.01); A61K 47/69 (2017.01); A61P 31/16 (2006.01); A61P 35/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6937 (2017.08); A61K 9/06 (2013.01); A61K 39/015 (2013.01); A61K 39/145 (2013.01); A61K 39/21 (2013.01); A61K 39/39 (2013.01); A61P 31/16 (2018.01); A61P 35/00 (2018.01); A61K 2039/54 (2013.01); A61K 2039/55577 (2013.01); A61K 2039/55588 (2013.01); A61K 2039/6093 (2013.01);
Abstract

An immunomodulatory delivery system includes a hydrogel, a first immunomodulatory cargo encapsulated in the cargo, and a second immunomodulatory cargo encapsulated in the hydrogel. The hydrogel includes a polymer non-covalently crossed-linked with a plurality of nanoparticles. The first immunomodulatory cargo is smaller than the second immunomodulatory cargo. A ratio of a diffusivity of the first immunomodulatory cargo through the hydrogel to a diffusivity of the second immunomodulatory cargo through the hydrogel is less than 3.


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