The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 07, 2025

Filed:

May. 29, 2024
Applicant:

Zymeworks Bc Inc., Vancouver, CA;

Inventors:

James R. Rich, Vancouver, CA;

Stuart Daniel Barnscher, Vancouver, CA;

Mark Edmund Petersen, Vancouver, CA;

Raffaele Colombo, Vancouver, CA;

Michael G. Brant, Vancouver, CA;

Manuel Michel Auguste Lasalle, Vancouver, CA;

Rupert H. Davies, Seattle, WA (US);

Dunja Urosev, Vancouver, CA;

Sukhbir Singh Kang, Vancouver, CA;

Peter Wing Yiu Chan, Vancouver, CA;

Samir Das, Vancouver, CA;

Andrea Hernandez Rojas, Vancouver, CA;

Robert William Gene, Vancouver, CA;

Ada G. H. Young, Vancouver, CA;

Samuel Oliver Lawn, Vancouver, CA;

Danny Chui, Vancouver, CA;

Duncan Browman, Vancouver, CA;

Brandon Clavette, Vancouver, CA;

Assignee:

Zymeworks BC Inc., Vancouver, CA;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 47/68037 (2023.08); A61K 47/6849 (2017.08); A61K 47/6889 (2017.08); A61P 35/00 (2018.01); C07K 16/28 (2013.01);
Abstract

Antibody-drug conjugates (ADCs) comprising an antibody construct that binds specifically binds human folate receptor alpha (FRα) (an anti-FRα antibody construct) conjugated to a camptothecin analogue of Formula (I). The ADCs are useful as therapeutics, in particular in the treatment of cancer.


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