The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2025
Filed:
Feb. 22, 2023
Applicant:
Massachusetts Institute of Technology, Cambridge, MA (US);
Inventors:
Darrell J. Irvine, Arlington, MA (US);
Karl Dane Wittrup, Boston, MA (US);
Tyson Moyer, Boston, MA (US);
Yash Agarwal, Cambridge, MA (US);
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 33/08 (2006.01); A61K 38/19 (2006.01); A61K 38/20 (2006.01); A61P 35/00 (2006.01); C07K 14/52 (2006.01); C07K 14/525 (2006.01); C07K 14/54 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 39/3955 (2013.01); A61K 33/08 (2013.01); A61K 38/191 (2013.01); A61K 38/195 (2013.01); A61K 38/20 (2013.01); A61P 35/00 (2018.01); C07K 14/521 (2013.01); C07K 14/525 (2013.01); C07K 14/54 (2013.01); C07K 16/2809 (2013.01); C07K 2319/30 (2013.01);
Abstract
The present disclosure provides immunomodulatory fusion proteins-metal hydroxide complexes comprising an immunomodulatory domain adsorbed to a metal hydroxide via ligand exchange. The disclosure also features compositions and methods of using the same, for example, to treat cancer.