The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2025
Filed:
Dec. 09, 2020
Applicant:
Alexion Pharmaceuticals, Inc., Boston, MA (US);
Inventors:
Walter C. Voegtli, Killingworth, CT (US);
Michael Baranello, Boston, MA (US);
Keith Bouchard, Boston, MA (US);
Assignee:
Alexion Pharmaceuticals, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/46 (2006.01); A61K 9/00 (2006.01); A61K 47/02 (2006.01); A61P 19/08 (2006.01); C12N 9/16 (2006.01);
U.S. Cl.
CPC ...
A61K 38/465 (2013.01); A61K 9/0019 (2013.01); A61K 47/02 (2013.01); A61P 19/08 (2018.01); C12N 9/16 (2013.01); C12Y 301/03001 (2013.01); C07K 2319/30 (2013.01);
Abstract
Featured are polypeptides that include soluble alkaline phosphatases, mutants, fragments, fusion proteins thereof, and methods of use thereof, for treating bone mineralization disorders, such as hypophosphatasia (HPP), and symptoms thereof. The polypeptides include a soluble alkaline phosphatase (sALP) or fragment thereof, which is derived from a naturally occurring alkaline phosphatase (ALP).