The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2025
Filed:
Jul. 27, 2018
Applicant:
National University of Singapore, Singapore, SG;
Inventors:
Assignee:
National University of Singapore, Singapore, SG;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/50 (2006.01); A61K 9/107 (2006.01); A61K 9/1271 (2025.01); A61K 9/1278 (2025.01); C12N 5/0786 (2010.01);
U.S. Cl.
CPC ...
A61K 9/5068 (2013.01); A61K 9/1075 (2013.01); A61K 9/1271 (2013.01); A61K 9/1278 (2013.01); C12N 5/0645 (2013.01); C12N 2509/10 (2013.01); C12N 2527/00 (2013.01);
Abstract
The present invention provides a biomolecular composite which is a ghost cell which has been emptied of all or substantially all of the cytosolic contents of the cell including the nucleus and nuclear contents, preferably further having been fused with exogenous amphipathic molecules, wherein said composite has a hydrodynamic diameter of less than 6 μm. The biomolecular composite may contain a cargo molecule and be capable of targeting a cell or tissue. Also provided are methods of preparing ghost cells, methods of preparing biomolecular composites and methods for their use.