The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 07, 2025

Filed:

Mar. 08, 2019
Applicant:

Arcus Biosciences, Inc., Hayward, CA (US);

Inventors:

Juan Carlos Jaen, Burlingame, CA (US);

Jenna Leigh Jeffrey, Oakland, CA (US);

Lixia Jin, San Mateo, CA (US);

Jaroslaw Kalisiak, Mountain View, CA (US);

Joyson J. Karakunnel, Potomac, MD (US);

Kenneth V. Lawson, San Francisco, CA (US);

Manmohan Reddy Leleti, Dublin, CA (US);

Jay Patrick Powers, Pacifica, CA (US);

Assignee:

ARCUS BIOSCIENCES, INC., Hayward, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 31/7076 (2006.01); A61K 45/06 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 9/0019 (2013.01); A61K 31/7076 (2013.01); A61K 45/06 (2013.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01);
Abstract

Methods of identifying compounds that modulate the conversion of AMP to adenosine by 5'-nucleotidase, ecto, and that possess particular pharmacokinetic characteristics are described herein. Methods of such compounds, and compositions comprising same, for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, are also provided.


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