The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 2025
Filed:
Aug. 16, 2017
The Broad Institute, Inc., Cambridge, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Rutgers, the State University of New Jersey, New Brunswick, NJ (US);
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Sergey Shmakov, Moscow, RU;
Kira S. Makarova, Bethesda, MD (US);
Yuri I. Wolf, Bethesda, MD (US);
Aaron Smargon, Cambridge, MA (US);
Neena Pyzocha, Cambridge, MA (US);
David Cox, Cambridge, MA (US);
Winston Yan, Brookline, MA (US);
David Scott, Cambridge, MA (US);
Konstantin Severinov, Piscataway, NJ (US);
Feng Zhang, Cambridge, MA (US);
Eugene V. Koonin, Bethesda, MD (US);
Broad Institute, Inc., Cambridge, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Rutgers, The State University of New Jersey, New Brunswick, NJ (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Abstract
Disclosed here is a method of identifying novel CRISPR effectors, comprising: identifying sequences in a genomic or metagenomic database encoding a CRISPR array; identifying one or more Open Reading Frames (ORFs) in said selected sequences within 10 kb of the CRISPR array; discarding all loci encoding proteins which are assigned to known CRISPR-Cas subtypes and, optionally, all loci encoding a protein of less than 700 amino acids; and identifying putative novel CRISPR effectors, and optionally classifying them based on structure analysis.