The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 30, 2025

Filed:

Jun. 28, 2022
Applicant:

Bull Sas, Les Clayes-sous-bois, FR;

Inventors:

Dmitri Gryzlov, Reigate, GB;

Jeroen Vermeulen, Madrid, ES;

Ioannis Bistinas, Amsterdam, NL;

Jurian Kuyvenhoven, Den Bosch, NL;

Quentin Creed, Brighton, GB;

Assignee:

BULL SAS, Les Clayes-sous-Bois, FR;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); C12M 1/06 (2006.01); C12M 1/34 (2006.01); C12M 1/36 (2006.01); G05B 13/02 (2006.01); G05B 13/04 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0602 (2013.01); C12M 27/06 (2013.01); C12M 41/12 (2013.01); C12M 41/36 (2013.01); C12M 41/40 (2013.01); C12M 41/42 (2013.01); C12M 41/48 (2013.01); G05B 13/0265 (2013.01); G05B 13/048 (2013.01);
Abstract

A method for optimizing a process (PROC) to produce a biochemical product (P) defined by a quality attribute, the process being controlled by an actuation parameter (C) and being monitored to get a measured value (T). The method includes training a predictive model (PRED) on a training database; and deploying the trained predictive model (PRED) to provide a correction actuation parameter (dC) when a predicted quality attribute (pQA) is out of a targeted quality attribute interval (QAmin, QAmax). The method also includes a step of designing a physical model of the process (PROC) able to provide a simulated quality attribute, the training database comprising simulated quality attributes computed from the physical model and experimental quality attributes computed from biochemical products (P) previously produced.


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