The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 2025
Filed:
Apr. 03, 2020
Celgene Corporation, Summit, NJ (US);
Haralambos Hadjivassiliou, Summit, NJ (US);
Dan Zhu, Summit, NJ (US);
Jeonghoon Sun, Summit, NJ (US);
Sharmistha Acharya, Summit, NJ (US);
Jeffrey Johnson, Summit, NJ (US);
Henry Chan, Summit, NJ (US);
Kandasamy Hariharan, Summit, NJ (US);
Ho Cho, Summit, NJ (US);
CELGENE CORPORATION, Summit, NJ (US);
Abstract
Antibodies are provided which comprise at least one Fab portion that binds CD47 and at least one Fab portion that binds the tumor associated antigen (TAA) CD20; wherein the Fab portion that binds CD47 exhibits low affinity for CD47; and, wherein the Fab portion that binds CD20 exhibits high affinity for CD20; and, wherein the antibody selectively binds CD47 and blocks CD47 interaction with SIRPα in tumor cells while exhibiting no substantial binding to CD47 in normal cells.