The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 2025
Filed:
Aug. 08, 2022
Harbour Biomed (Shanghai) Co., Ltd, Shanghai, CN;
Ming-Jin Jheng, Shanghai, CN;
Yongqiang Wang, Shanghai, CN;
Yun Zhang, Shanghai, CN;
Chuchu Zhao, Shanghai, CN;
Yunxing Yang, Shanghai, CN;
Fei Chen, Shanghai, CN;
Beibei Qin, Shanghai, CN;
Yuetao Wu, Shanghai, CN;
Yi Ding, Shanghai, CN;
HARBOUR BioMed (Shanghai) Co., Ltd, Shanghai, CN;
Abstract
The present invention discloses CLDN18.2-targeting antibodies, bispecific antibodies and use thereof. The CLDN18.2-targeting antibody is a single-domain heavy-chain antibody that has high affinity for tumor cells endogenously expressing CLDN18.2 and can induce high endocytic activity. The bispecific antibody can target CLDN18.2 and CD3 and retains the binding effect of an Fc to an FcRn; meanwhile, a mutant Fc is preferred so as to reduce the binding to an FcgR and thus the activation of non-specific T cells caused by the cross-linking of an FcgR. The CD3-terminus activity is optimized so that the release of common cytokines in CRS, such as IL6 and TNFα can be reduced.