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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12428463 B1

PDFFull Text
Date of Patent:
Sep. 30, 2025

Filed:

Aug. 01, 2023

Chimeric antigen receptors targeting abnormal glycobiology

Applicant:

The Regents of the University of Michigan, Ann Arbor, MI (US);

Inventors:

Challice L. Bonifant, Towson, MD (US);

Alnawaz Rehemtulla, Plymouth, MI (US);

David M. Markovitz, Ann Arbor, MI (US);

Assignee:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);

Attorneys:

David W. Staple

Casimir Jones, S.C.

Primary Examiner:

Peter J Reddig

Int. Cl.
CPC ...
C07K 14/725 (2006.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); A61P 35/00 (2018.01); C07K 14/70517 (2013.01); C07K 14/70575 (2013.01); C12N 5/0636 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); C07K 2319/02 (2013.01);
Abstract

The disclosure provides a chimeric antigen receptor (CAR) polypeptide having an antigen binding domain comprising an extracellular lectin which specifically binds to glycoproteins expressed on the surface of target cells. Also provided herein are engineered lymphocytes expressing the CAR polypeptide, a nucleic acid molecule encoding the CAR polypeptide, and methods of treating cancer.

Find Patent Forward Citations

Bonifant, Challice. (2025). Chimeric antigen receptors targeting abnormal glycobiology (U.S. Patent No. 12428463). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12428463

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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