The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 2025
Filed:
Feb. 08, 2021
Applicants:
The Trustees of Columbia University IN the City of New York, New York, NY (US);
The Regents of the University of California, Oakland, CA (US);
Inventors:
Lloyd A. Greene, Larchmont, NY (US);
Xiaotian Sun, Fort Lee, NJ (US);
James M. Angelastro, David, CA (US);
Assignees:
The Trustees of Columbia University in the City of New York, New York, NY (US);
The Regents of the University of California, Oakland, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); A61K 31/337 (2006.01); A61K 31/4706 (2006.01); A61K 31/704 (2006.01); A61K 38/17 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/47 (2013.01); A61K 31/337 (2013.01); A61K 31/4706 (2013.01); A61K 31/704 (2013.01); A61K 38/1709 (2013.01); A61P 35/00 (2018.01); C07K 2319/10 (2013.01);
Abstract
Dominant negative forms of CEBPB and CEBPD, and cell-penetrating forms thereof are described. Methods for using the dominant negative forms of CEBPB and CEBPD proteins, and cell-penetrating forms thereof, for decreasing viability of neoplastic cells and treating cancer in a subject are also described.